本片改编自推理小说家知念实希人的同名小说，背景设定在被铁栅栏封闭的原精神科医院，讲述在监狱里发生了监禁64名身份不明的住院患者和职员的事件，被牵连的速水(坂口饰)在医院内接连遇到不可思议的事情，并试图逃出的故事。Shugo Hayami is a doctor at a nursing hospital, which was once a psychiatric hospital. One evening, when Shugo is on night duty, a man in pierrot mask breaks into the hospital and he is not alone. He is with Hitomi Kawasaki, a university student who has been shot by the masked man. The masked man tells Shugo to treat Hitomi. He also takes hostage the 64 people in the hospital. Soon, Shugo and Hitomi try to escape from the hospital and they encounter mysterious cases one at a time.
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